Sounds interesting. I do not think it is an user or setting, it seems like a driver issue or similar which (after some time) may provide information which causes confusion.
The best would be to use
1) Report menu -> Send test report to developer option after startup, when everything is fine
2) Report menu -> Send test report to developer option after you see the problem, when partial information is displayed (without restart)
This would help to check the response from the controller and verify what can be wrong.
Even if the hard disks should not spin down because of the Windows power management settings, some controllers may use their own power management function which can activate.
You may try to use Configuration -> Disk Control -> Do not allow spin down of disks option, just speciy a * to that field. This way Hard Disk Sentinel periodically sends a command, causing the that the drives should (really) keep spinning and the controller should maintain the connection. This may help, but the above mentioned reports would be nice to investigate the actual situation.