Yes of course.
Please check Support -> Frequently Asked Questions -> Is it possible to monitor disk status WITHOUT administrator rights? topic:
Use Configuration -> Integration -> Use as service button. It switches Hard Disk Sentinel Professional to "service" mode: then it runs in the context of the SYSTEM account, invisible in the background as an NT service and works independenty from the current user, without any visible user interface.
This way it can work (detect status, issue alerts by e-mail, report problems) independently from the current user and his user rights, so works even if the current user has limited user rights - or if there is no logged user at all. So in service mode, Hard Disk Sentinel Pro is separated from the current user.
It is good idea to combine with some options, eg. the WMI integration, so you can check disk status via WMI:
or access the status information by XML: